GenomeSpace Tools and Data Sources
Cancer Cell Line Encyclopedia
Project Website: http://www.broadinstitute.org/ccle
Datasets from the Cancer Cell Line Encyclopedia (CCLE) project are now linked to GenomeSpace. The CCLE project aims to characterize the genetics and pharmacology of a large panel of human cancer models and to develop integrated computational analyses that link pharmacologic sensitivities to genomic patterns. In addition to the pharmacologic analysis and annotations for about 1000 cell lines, data include DNA copy number, mRNA expression, Oncomap 3.0 mutation, and hybrid capture mutation analyses. The project is ongoing and datasets may be released before publication.
To send data, click on the GenomeSpace icon next to the dataset name.
The related 2012 Nature publication is titled The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. The CCLE project is a collaboration between the Broad Institute of MIT and Harvard, and the Novartis Institutes for Biomedical Research and its Genomics Institute of the Novartis Research Foundation.